Description Manhattan's Chinatown home to the largest enclave of Chinese people in the Western hemisphere, is located in the borough of Manhattan in New York City, bordering Lower East Side to the east and Little Italy to the north.With an estimated population of 90,000 to 100,000 people, Manhattan's Chinatown is also one of the oldest ethnic Chinese enclaves outside of Asia, with many of its residents Cantonese-speaking and originating from various regions of China, mainly from Guangdong and Fujian,FJ provinces, and Hong Kong. It is one of three Chinatown neighborhoods in New York City, with the two others located in the boroughs of Queens and Brooklyn.(Wikipedia)